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A ‘dented’ internal clock provides insight into shift workers’ weight gain and diabetes

A study of “dented” internal clocks seems to have provided evidence for a theory as to why people who work late or irregular hours are susceptible to weight gain and diabetes. High rates of shift workers gain weight and develop diabetes, which has been attributed to a mismatch between their internal clocks and their schedules, so researchers from the Perelman School of Medicine at the University of Pennsylvania created a related mismatch by altering the function of a molecule within the brains of mice that shortened their circadian rhythms from 24 to 21 hours. These mice gained more weight, had higher blood sugar, and fattier livers, all of which were corrected by changing their environment to a 21-hour “day.” Read More

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