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Antidiabetic activity of Nigella Sativa and its active constituent thymoquinone.


Chonnam Med J. 2021 Sep ;57(3):169-175. Epub 2021 Sep 24. PMID: 34621636

Abstract Title: 

Antidiabetic Activity of(Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies.


The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity ofas many type 2 diabetic patients use it as a complementary therapy along with their modern allopathic medications or as an alternative therapy. The literature was reviewed in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, Directory of open access journals (DOAJ), and reference lists to identify relevant articles supporting the use ofin diabetes management. Numerous clinical and animal studies have demonstrated the antidiabetic efficacy of black seeds () and its major bioactive constituent thymoquinone. Based on these findings patients with diabetes may useas an adjuvant therapy, which may help to reduce the dose and incidence of adverse effects of modern antidiabetic medicines.

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