Int J Antimicrob Agents. 2021 Jun 28:106394. Epub 2021 Jun 28. PMID: 34197906
Artemisinin elevates the ergosterol levels of Candida albicans to synergize with amphotericin B against oral candidiasis.
Oral candidiasis, especially caused by Candida albicans, is the most common fungal infection in the oral cavity. The increase of drug resistance and lack of new antifungal agents call for new strategies of fungal treatment. This study repurposed artemisinin (Art) as a potentiator to amphotericin B (AmB) and characterized their synergistic mechanism against C. albicans and oral candidiasis. The synergistic antifungal activities between Art and AmB were identified through the checkerboard and recovered plate assays according to the fractional inhibitory concentration index (FICI). Art showed no antifungal ability even at>200 mg/L. However, it significantly reduced the AmB dosages against the wild-type strain and 75 clinical isolates of C. albicans (FICI