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Could childhood inflammation or infection be a cause of depression and psychosis?

A growing body of research suggests that early-life infection, inflammation, and metabolic changes could contribute to psychiatric disorders—perhaps via effects during critical periods of brain development. New evidence on how “immunometabolic” risk factors in childhood may affect the development of depression and psychotic disorders in adulthood is presented in the January/February special issue of Harvard Review of Psychiatry.
If confirmed, this line of research might lead to new approaches to treating depression and psychosis in adults—and possibly efforts to prevent these disorders by targeting early-life immunometabolic risk factors in childhood, according to the report by Nils Kappelmann, Ph.D., of Max-Planck-Institute of Psychiatry, Munich, and colleagues. The study is one of seven special issue papers exploring possible links between inflammation and mental health disorders. Read More

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