Asian Pac J Cancer Prev. 2019 09 1 ;20(9):2831-2840. Epub 2019 Sep 1. PMID: 31554384
Cytotoxicity Profiling of Annona Squamosa in Cancer Cell Lines.
Objective: In the study our aim was to evaluate the cytotoxic activity of different solvent extracts of Annona
squamosa seeds. Methods and materials: The four extracts used were petroleum ether, chloroform, ethyl acetate
and methanol were tested using cytotoxicity assays. Results: Among the four extracts tested petroleum ether showed
maximum cytotoxicity against a panel of cancer cell lines such as nasopharyngeal cancer (KB) cells, lung cancer
(A-549) cells, breast cancer (MCF- 7) cells, leukemic (K-562) cells and inhibited the growth of murine cancer cells
such as Dalton’s lymphoma ascites (DLA) and Ehrlich ascites carcinoma (EAC). Conclusion: Petroleum ether extract
of Annona squamosa seeds showed cytotoxicity towards a panel of cancer cells meanwhile non-significant cytotoxicity
towards normal cells.