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Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model.


Food Chem Toxicol. 2013 Mar ;53:294-8. Epub 2012 Dec 20. PMID: 23261675

Abstract Title: 

Dieckol isolated from brown seaweed Ecklonia cava attenuates typeІІ diabetes in db/db mouse model.


In the present study, the attenuation of typeІІ diabetes by dieckol, a phlorotannin derivative isolated from brown seaweed, Ecklonia cava was investigated in C57BL/KsJ-db/db, a type ІІ diabetes mouse model. Dieckol was administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight diabetes mice for 14 days. The blood glucose level, serum insulin level and body weight were significantly reduced in the dieckol administered group, compared to that of the saline administered group. Furthermore, reduced thiobarbituric acid reactive substraces (TBARS), as well as increased activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) in liver tissues were observed in the dieckol administered group. In addition, increased levels of the phosphorylation of AMPK and Akt were observed in the muscle tissues of the dieckol administered group in a Western blottinganalysis. According to the findings of this study, it could be suggested that, dieckol can be developed as a therapeutic agent for type ІІ diabetes.

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These result indicated that dieckol might be a potent inhibitor for α-glucosidase and α-amylase.

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