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Nephroprotective effect of persimmon leaves ( Diospyros kaki L.f.) against CCl 4-induced renal toxicity.


Drug Chem Toxicol. 2021 Jan 31:1-9. Epub 2021 Jan 31. PMID: 33522322

Abstract Title: 

Nephroprotective effect of persimmon leaves (L.f.) against CCl-induced renal toxicity in Swiss Albino rats.


L.f. fruit and leaves are traditionally used for the treatment of hypertension, angina, internal hemorrhage, antithrombotic and anti-inflammatory effects.In the current study, the protective effects of ethyl acetate (Per-1),-butanol (Per-2), and aqueous (Per-3) fractions ofleaves against carbon tetrachloride (CCl) induced nephrotoxicity in Swiss albino rats were tested. Animal were divided into nine groups; each group consists of six animals. The groups were : group I was untreated and kept as control, group II was treated with CClonly, group III (silymarin with CCl); group IV (Per-1 100 mg/kg with CCl);group V (Per-1 200 mg/kg with CCl); group VI (Per-2 100 mg/kg with CCl); group VII (Per-2 200 mg/kg with CCl); group VIII (Per-3 100 mg/kg with CCl); and group IX (Per-3 200 mg/kg with CCl). Silymarin was used as standard drug. All tested fractions were found active (except Per-1 at low dose of 100 mg/kg) with significant value ( 

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