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New opportunities for targeting overactive cancer genes

Anita Göndör’s group has identified a new mechanism underlying the pathological over-expression of cancer genes. The results, which are published in Nature Communications show that signals in the environment of the cancer cell exploit a CTCF-bound super-enhancer to recruit cancer genes to the nuclear pore in a multistep process that involves a non-coding RNA. This discovery provides new opportunities for targeting overactive cancer genes without interfering with their functions in normal cells. Read More

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