Saudi Pharm J. 2017 May ;25(4):638-643. Epub 2017 May 10. PMID: 28579904
Oridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling.
BACKGROUND: Oridonin is a diterpenoid isolated fromwith potent anticancer activity. The aim of our study is to investigate the role of oridonin to inhibit growth and metastasis of human breast cancer cells.METHODS: The effect of oridonin on proliferation was evaluated by MTT assay, cell migration and invasion were evaluated by transwell migration and invasion assays in human breast cancer cells. The inhibitive effect of oridoninwas determined by using xenografted nude mice. In addition, the expression of Notch receptors (Notch 1-4) was detected by western blot.RESULTS: Oridonin inhibited human breast cancer cellsand. In addition, oridonin significantly induced human breast cancer cells apoptosis. Furthermore, the oridonin treatment not only inhibited cancer cell migration and invasion, but more significantly, decreased the expression of Notch 1-4 protein.CONCLUSION: Our results suggest that the inhibitive effect of oridonin is likely to be driven by the inhibition of Notch signaling pathway and the resulting increased apoptosis.