Arabic Arabic English English French French German German

Potential of the ellagic acid-derived gut microbiota metabolite – urolithin A in gastrointestinal protection.


World J Gastroenterol. 2020 Jun 21 ;26(23):3170-3181. PMID: 32684733

Abstract Title: 

Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection.


Urolithin A (UA) is a metabolic compound generated during the biotransformation of ellagitannins by the intestinal bacteria. The physiologically relevant micromolar concentrations of UA, achieved in the plasma and gastrointestinal tract (GI) after consumption of its dietary precursors, have been revealed to offer GI protection. The health benefit has been demonstrated to be principally related to anticancer and anti-inflammatory effects. UA has been shown to possess the capability to regulate multiple tumor and inflammatory signaling pathways and to modulate enzyme activity, including those involved in carcinogen biotransformation and antioxidant defense. The purpose of this review is to gather evidence from bothandstudies showing the potential of UA in GI protection alongside suggested mechanisms by which UA can protect against cancer and inflammatory diseases of the digestive tract. The data presented herein, covering both studies on the pure compound andgenerated UA form its natural precursor, support the potential of this metabolite in treatment interventions against GI ailments.

read more

Read More

Leave a Reply

Your email address will not be published. Required fields are marked *

Previous Post

Gut Viromes Are Highly Individualized, Yet Reveal Shared Patterns

Next Post

Mom transmitted coronavirus to baby in womb, Dallas physicians say

Related Posts