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Researchers clarify the role of the two isoforms of KRAS, the most common oncogene in humans

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 percent of human tumors. The development of KRAS inhibitors is, thus, an extremely active line of research. Effective results have been elusive so far, though—no KRAS inhibitor had been available until a month ago, when the FDA granted approval to Sotorasib. Read More

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