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Researchers uncover new mechanism for deadly blood clots

Nearly 80 percent of deaths from type 2 diabetes mellitus (T2DM) are associated with thrombosis, a condition that occurs when blood clots block a vein or artery. Traditionally, it’s been thought that proteins released by damaged blood vessels may lead to inappropriate blood clotting, but a new study from investigators at Brigham and Women’s Hospital points to another trigger and a new mechanism that may underlie thrombosis. Beginning with samples from patients, investigators identified the new mechanism that activated PIEZO1, a major mechanosensory ion channel. In the lab, the team examined its effects and its potential as a therapeutic target for preventing thrombosis or identifying people at heightened risk. The team’s results are published in Science Translational Medicine. Read More

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